How do the rotavirus NSP4 and bacterial enterotoxins lead differently to diarrhea?
نویسندگان
چکیده
منابع مشابه
Studies of the role for NSP4 in the pathogenesis of homologous murine rotavirus diarrhea.
A rotavirus (RV) nonstructural protein, NSP4, has recently been proposed to function as an enterotoxin in the pathogenesis of RV diarrhea. The role of NSP4 in the pathogenesis of RV diarrhea was examined by infecting cystic fibrosis transmembrane conductance regulator (CFTR) knockout mice with virulent murine RV and by comparing deduced amino acid sequences of RV gene 10 encoding NSP4 from thre...
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Among the various factors that are known to initiate the pathophysiological events leading to chronic, intractable diarrhea of infancy are intestinal infections by bacteria. Such infections, furthermore, are particularly worrisome in malnourished infants, where they tend to result more often in protracted diarrhea necessitating vigorous and risk-laden supportive treatment. Schematically, bacter...
متن کاملHigher Expression Level and Lower Toxicity of Genetically Spliced Rotavirus NSP4 in Comparison to the Full-Length Protein in E. coli
Background: Rotavirus group A (RVA) is recognized as a major cause of severe gastroenteritis in children and new-born animals. Nonstructural protein 4 (NSP4) is responsible for the enterotoxic activity of these viruses in the villus epithelial cells. Amino acids 114-135 of NSP4 are known to form the diarrhea-inducing region of this viral enterotoxin. Therefore, developing an NSP4 lacking the en...
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Chronic diarrhea is defined as passing watery stools that lasts for more than 2 weeks. Persistent diarrhea belongs to chronic diarrhea and is a chronic episode of diarrhea of infectious etiology. The etiology of chronic diarrhea is varied. It is important to consider the child's age and clinical manifestations with alarm signals for an application of proper treatments to children with chronic d...
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ژورنال
عنوان ژورنال: Virology Journal
سال: 2007
ISSN: 1743-422X
DOI: 10.1186/1743-422x-4-31